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Vanda’s experimental COVID-19 drug shows promise in interim trial data

first_imgCOVID-19 patients with pneumonia improved faster when treated with Vanda Pharmaceuticals Inc’s experimental therapy than those on placebo, the company said on Tuesday, citing an interim analysis of data from a late-stage study.Shares of the US drug developer rose over 13% before the opening bell.While the data from 60 patients showed that a 14-day treatment with the drug, tradipitant, helped speed up clinical improvements by day seven, the company warned a larger patient size was needed to confirm the benefit. So far, Gilead Sciences Inc’s antiviral remdesivir and the generic steroid dexamethasone have been shown to help patients with COVID-19 in rigorous clinical trials.The US drug developer, which licensed tradipitant from Eli Lilly and Co in 2012, eventually plans to enroll 300 patients in the late-stage trial.The US Food and Drug Administration (FDA) has imposed a partial clinical hold on tradipitant trials that are longer than 12 weeks, citing the need for additional studies before testing the drug in humans beyond that timeframe. A US court sided with the FDA in January over a legal dispute related to the agency’s decision.The drug is also being tested as a treatment for various conditions including atopic dermatitis and motion sickness. The company says the drug targets a receptor in the body that could be associated with causing lung injury.Vanda said the drug’s properties as an anti-inflammatory agent would complement antiviral drugs for COVID-19, if the results from its analysis were confirmed.Topics :last_img read more

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Governor Wolf Applauds Legislature for Cementing His Pennsylvania Business One-Stop Shop into Statute

first_imgGovernor Wolf Applauds Legislature for Cementing His Pennsylvania Business One-Stop Shop into Statute SHARE Email Facebook Twitter October 18, 2018center_img Economy,  Jobs That Pay,  Press Release Harrisburg, PA – Today, Governor Tom Wolf applauded the legislature for the passage of House Bill 1284, which codifies into statute the governor’s PA Business One-Stop Shop initiative designed to help entrepreneurs in all stages of starting and running a business.“As a former business owner, I know that for too long the processes and procedures for starting and running a business were a barrier to entry for so many entrepreneurs across the commonwealth,” Governor Wolf said. “I’m proud that my PA Business One-Stop Shop has successfully eased that burden on entrepreneurs. I applaud the legislature for recognizing that success and cementing the one-stop shop into statute.”The PA Business One-Stop Shop was developed to address identified areas of need for entrepreneurs and small business owners across the commonwealth and assists with planning a business, registration and permitting, hiring employees, and funding and technical assistance. The PA Business One-Stop Shop consolidates information from many agencies into one easy-to-use website. It is intended to take the guesswork out of many business operations and procedures and serves as an equalizer for any who want to start and run a business in Pennsylvania.Governor Wolf initially proposed the PA Business One-Stop Shop in his budget address for the 2017-18 fiscal year, and officially launched the program one year later during his 2018-2019 budget address in February 2018. The One-Stop Shop has quickly built momentum since launch, generating more than 71,000 unique visits to the website and receiving critical buy-in and support from partners across the commonwealth like Small Business Development Centers. When Governor Wolf signs HB1284 into law, it will cement the PA Business One-Stop Shop into statute and secure its future.In addition to the PA Business One-Stop Shop website, aspiring entrepreneurs or current business owners can also call a phone number, (833)722-6778, to connect to a team of dedicated business consultants and subject matter experts who can answer questions. Together, the website and team of experts will help guide and support businesses through all stages of development from planning and startup to operation and expansion.The PA Business One-Stop Shop can be found at business.pa.gov. For more information about the Wolf Administration’s commitment to helping businesses grow and thrive, visit the DCED website or follow us on Twitter, LinkedIn, Facebook, and YouTube.last_img read more